Exam Guide

Interpreting an ABG in a COPD Exacerbation

Respiratory · Question from the ATI RN Medical-Surgical 2023 Proctored Exam study set

Question: A patient with Chronic Obstructive Pulmonary Disease (COPD) has a pH of 7.33 and a pCO2 of 50. This is:
A. Metabolic Acidosis
B. Respiratory Acidosis
C. Metabolic Alkalosis
D. Respiratory Alkalosis

Correct answer: B. Respiratory Acidosis

Why this is the answer

A pH below 7.35 confirms acidosis, and an elevated pCO2 points to a respiratory cause — the lungs are retaining CO2, which is exactly what happens when COPD impairs gas exchange. Metabolic Acidosis (A) is ruled out because a metabolic problem would show a low bicarbonate driving the pH down, not an elevated pCO2. Metabolic Alkalosis (C) is wrong on two counts — the pH here is low, not high, and the disturbance is respiratory, not metabolic. Respiratory Alkalosis (D) would require a low pCO2 (from hyperventilation) paired with a high pH — the opposite of what's shown here.

The bigger concept

The quick rule for classifying an ABG: check the pH direction first (acidic vs alkalotic), then check whether pCO2 or HCO3 is driving it — an abnormal pCO2 points to a respiratory cause, an abnormal HCO3 points to a metabolic one. COPD is the textbook cause of chronic respiratory acidosis from CO2 retention.

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